RRM2 Antikörper (Ribonucleotide Reductase M2) (Cy5)

Details for Product anti-RRM2 Antibody No. ABIN1704987
Antigen
  • R2
  • RR2
  • RR2M
  • AA407299
  • rrm2
  • rr2m
  • cb111
  • chunp6884
  • r2
  • ribonucleotide reductase regulatory subunit M2
  • ribonucleotide reductase M2
  • ribonucleotide reductase M2, gene 2 L homeolog
  • ribonucleotide reductase M2, gene 1
  • ribonucleotide reductase M2 polypeptide
  • RRM2
  • Rrm2
  • rrm2.2.L
  • rrm2.1
  • rrm2
Reaktivität
Human, Maus, Ratte (Rattus)
86
38
38
2
2
1
1
1
Wirt
Kaninchen
71
13
2
Klonalität
Polyklonal
Konjugat
Dieser RRM2 Antikörper ist konjugiert mit Cy5
5
3
3
3
3
3
3
3
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
58
26
19
16
14
12
12
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human RRM2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere RRM2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Rrm2 (RRM2 Antibody Abstract)
Hintergrund

Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage.

Synonyms: R2, Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase M2 subunit, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit, RIR2_HUMAN, RR2, RR2M, RRM2.

Gen-ID 6241
Pathways Mitotic G1-G1/S Phases
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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