GEM Antikörper (GTP Binding Protein Overexpressed in Skeletal Muscle) (Cy5)

Details for Product anti-GEM Antibody No. ABIN1704918
Antigen
  • KIR
  • GEM
  • DKFZp470D0612
  • LOC100221129
  • kir
  • xgem
  • zgc:153003
  • Gem
  • AV020497
  • GTP binding protein overexpressed in skeletal muscle
  • geminin, DNA replication inhibitor
  • GTP binding protein (gene overexpressed in skeletal muscle)
  • GEM
  • gem
  • Gem
  • GMNN
Reaktivität
Human, Maus, Ratte (Rattus)
61
30
27
6
4
4
4
4
3
2
2
1
1
Wirt
Kaninchen
42
15
4
Klonalität
Polyklonal
Konjugat
Dieser GEM Antikörper ist konjugiert mit Cy5
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
48
27
12
11
8
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GEM
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GEM products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Gem (GEM Antibody Abstract)
Hintergrund

Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodulin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278â€"297 in human Rad. High intracellular Gem levels, which interact with intact microtubules and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimulate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regulates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome ,8q22.1.

Synonyms: GTP binding mitogen induced T cell protein, GTP binding protein expressed in mitogen stimulated T cells, GTP binding protein GEM, GTP binding protein overexpressed in skeletal muscle, Kinase inducible Ras like protein, KIR, MGC26294, RAS like protein KIR, GEM_HUMAN.

Gen-ID 2669
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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