Stratifin Antikörper (SFN) (Cy5)

Details for Product anti-SFN Antibody No. ABIN1704707
Antigen
  • YWHAS
  • Er
  • Mme1
  • Ywhas
  • stratifin
  • SFN
  • Sfn
Reaktivität
Human, Maus, Ratte (Rattus)
207
86
70
16
13
13
11
8
8
7
5
4
2
1
1
1
1
1
Wirt
Kaninchen
165
28
22
1
1
Klonalität
Polyklonal
Konjugat
Dieser Stratifin Antikörper ist konjugiert mit Cy5
16
10
7
6
5
5
4
4
4
4
4
3
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
167
77
77
42
40
18
18
16
12
8
3
3
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human 14-3-3 sigma
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Stratifin products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung 14-3-3 sigma (SFN Antibody Abstract)
Hintergrund

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.

Synonyms: 14 3 3 protein sigma, 14-3-3 protein sigma, 1433S_HUMAN, Epithelial cell marker protein 1, Er, HME 1, HME1, MGC143283, Mkrn3, Mme1, OTTHUMP00000004242, RP23 137L22.11, SFN, SFN protein, Stratin, YWHAS.

Gen-ID 2810
Pathways p53 Signalweg, Myometrial Relaxation and Contraction
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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