FZR1 Antikörper (Fizzy/cell Division Cycle 20 Related 1 (Drosophila)) (Cy5)

Details for Product anti-FZR1 Antibody No. ABIN1704294
Antigen
  • CDH1-C
  • FYR
  • FZR
  • CDH1
  • fzr1
  • CDC20C
  • FZR2
  • HCDH
  • HCDH1
  • AW108046
  • Cdh1
  • Fyr
  • zgc:55450
  • fizzy and cell division cycle 20 related 1
  • fizzy/cell division cycle 20 related 1
  • fizzy-related protein homolog
  • fizzy/cell division cycle 20 related 1 (Drosophila)
  • fizzy/cell division cycle 20 related 1a
  • Fzr1
  • CDH1-C
  • FZR1
  • LOC100027495
  • LOC100179951
  • fzr1a
Reaktivität
Human, Maus, Ratte (Rattus)
87
38
34
3
3
3
3
3
2
2
2
1
1
1
Wirt
Kaninchen
76
11
Klonalität
Polyklonal
Konjugat
Dieser FZR1 Antikörper ist konjugiert mit Cy5
6
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
59
31
14
12
8
7
3
1
1
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human FZR1/CDC20C
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere FZR1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Fzr1/Cdc20c (FZR1 Antibody Abstract)
Hintergrund

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Subcellular location: Nucleus, Intracellular

Synonyms: FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

Gen-ID 51343
UniProt Q9UM11
Pathways DNA Replication, Synthesis of DNA
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
Haben Sie etwas anderes gesucht?