Exportin 1, CRM1 Homolog (Yeast) (XPO1) (AA 720-770) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704277
Antigen
  • CG13387
  • CRM1
  • Crm1
  • DCRM1
  • Dmel\\CG13387
  • Emb
  • XPO-1
  • XPO1
  • Xpo1
  • crm1
  • dCRM1
  • l(2)k16715
  • 18.m06600
  • DDBDRAFT_0183812
  • DDBDRAFT_0234066
  • DDB_0183812
  • DDB_0234066
  • exportin-1
  • LOC100220104
  • emb
  • exp1
  • Xpo
  • AA420417
  • Exp1
  • embargoed
  • exportin 1
  • putative exportin 1
  • chromosome region maintenance protein 1
  • exportin-1
  • exportin 1 (CRM1 homolog, yeast)
  • exportin 1 S homeolog
  • emb
  • cgd3_3060
  • Tc00.1047053511725.150
  • Tb11.01.5940
  • BBOV_II007220
  • LMJF_32_1100
  • xpo1
  • Xpo1
  • XPO1
  • LOC100165622
  • LOC100633509
  • xpo1.S
Epitop
AA 720-770
14
8
7
5
4
4
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
97
64
45
11
8
6
5
4
4
4
4
3
3
1
1
1
1
1
Wirt
Kaninchen
91
7
Klonalität
Polyklonal
Konjugat
Cy5
5
4
4
4
4
4
3
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
57
22
20
15
12
7
6
3
3
3
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Exportin 1/CRM1
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Exportin 1/CRM1 (XPO1 Antibody Abstract)
Hintergrund

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Subcellular location: Cytoplasm

Synonyms: emb, CRM1, exp1, Exportin-1, Chromosome region maintenance 1 protein homolog, XPO1

Gen-ID 7514
UniProt O14980
Pathways M Phase
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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