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Exportin 1 (XPO1) (AA 720-770) Antikörper (Cy5) Primary Antibody

XPO1 Reaktivität: Human, Maus, Ratte IF (p) Wirt: Kaninchen Polyclonal
Produktnummer ABIN1704277
$442.20
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 16 Werktagen
  • Target
    Bindungsspezifität
    AA 720-770
    Reaktivität
    Human, Maus, Ratte
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Konjugat
    Cy5
    Applikation
    Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Exportin 1/CRM1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 4°C
    Haltbarkeit
    12 months
  • Target
    Andere Bezeichnung
    Exportin 1/CRM1 (XPO1 Antibody Abstract)
    Synonyme
    CG13387, CRM1, Crm1, DCRM1, Dmel\\CG13387, Emb, XPO-1, XPO1, Xpo1, crm1, dCRM1, l(2)k16715, 18.m06600, DDBDRAFT_0183812, DDBDRAFT_0234066, DDB_0183812, DDB_0234066, exportin-1, LOC100220104, emb, exp1, Xpo, AA420417, Exp1, embargoed, exportin 1, putative exportin 1, chromosome region maintenance protein 1, exportin-1, exportin 1 (CRM1 homolog, yeast), exportin 1 S homeolog, emb, cgd3_3060, Tc00.1047053511725.150, Tb11.01.5940, BBOV_II007220, LMJF_32_1100, xpo1, Xpo1, XPO1, LOC100165622, LOC100633509, xpo1.S
    Hintergrund

    Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

    Subcellular location: Cytoplasm

    Synonyms: emb, CRM1, exp1, Exportin-1, Chromosome region maintenance 1 protein homolog, XPO1

    Gen-ID
    7514
    UniProt
    O14980
    Pathways
    M Phase
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