POU2AF1 Antikörper (POU Class 2 Associating Factor 1) (Cy5)

Details for Product anti-POU2AF1 Antibody No. ABIN1704238
Antigen
  • BOB1
  • OBF-1
  • OBF1
  • OCAB
  • BOB-1
  • BOB.1
  • Bob-1
  • Bob1
  • OBF.1
  • OCA-B
  • POU class 2 associating factor 1
  • POU domain, class 2, associating factor 1
  • POU2AF1
  • Pou2af1
Reaktivität
Human, Maus, Ratte (Rattus)
158
54
47
7
5
2
2
2
Wirt
Kaninchen
100
47
17
Klonalität
Polyklonal
Konjugat
Dieser POU2AF1 Antikörper ist konjugiert mit Cy5
11
9
9
5
5
5
4
4
4
4
4
3
2
2
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
107
74
39
25
25
17
7
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human BOB1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere POU2AF1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Bob1 (POU2AF1 Antibody Abstract)
Hintergrund

POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. The POU dimer from the OCT1 gene formed on the palindromic OCT factor recognition element, or PORE (ATTTGAAATGCAAAT), could recruit the transcriptional coactivator OBF1. Studies of tissue-specific expression of immunoglobulin promoters demonstrate the importance of an octamer, ATTTGCAT, and the proteins that bind to it. This is a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. Oct-1 encodes one protein, NF-A1, which is found in nuclear extracts from all cell types and thus is not specific to lymphoid cells as is the protein NF-A2, which is encoded by Oct-2. A novel protein designated Bob 1 (B cell Oct binding protein 1), alternatively called OBF-1, specifically interacts with Oct-1 and Oct-2, enhancing their transcriptional efficacy. Bob 1 is expressed at highest levels in spleen and peripheral blood leukocytes and represents an Oct co-factor capable of conferring cell-specific activation of Oct-1 and Oct-2. Although having no intrinsic capacity for DNA binding, Bob 1 associates tightly with the octamer motif in the presence of Oct-1 and/or Oct-2. The gene which encodes Bob 1 maps to human chromosome 11q23.1.

Synonyms: B cell Oct binding protein 1, B cell specic coactivator OBF 1, B cell specic coactivator OBF1, B-cell-specic coactivator OBF-1, BOB 1, BOB-1, OBF 1, OBF1, OBF1_HUMAN, OCA B, OCA-B, OCAB, OCT binding factor 1, OCT-binding factor 1, POU domain class 2 associating factor 1, POU domain class 2-associating factor 1, POU2AF1.

Gen-ID 5450
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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