EDD is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
Synonyms: 4432411E13Rik, AW549941, C77315, D030042K14, DD5, E3 identied by dferential display, E3 ubiquitin protein ligase, HECT domain containing, 1, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase UBR5, EDD 1, EDD, EDD, EDD1, FLJ11310, HECT domain-containing 1, hHYD, HYD, Hyperplastic discs protein homolog, KIAA0896, MGC57263, mKIAA0896, Progestin induced protein, Progestin-induced protein, Rat100, Ubiquitin protein ligase, Ubiquitin protein ligase E3 component n recognin 5, UBR5, UBR5_HUMAN.