FAK Antikörper (pSer910) (AbBy Fluor® 555)

Produktnummer ABIN1696856

Der Kaninchen Polyklonal Anti-FAK-Antikörper wurde für WB, IF (p) und IF (cc) validiert. Er ist geeignet, FAK in Proben von Maus, Ratte und Xenopus laevis zu detektieren.

Kurzübersicht für FAK Antikörper (pSer910) (AbBy Fluor® 555) (ABIN1696856)

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reaktivität: Maus, Ratte, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAK Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-FAK Antikörper (AbBy Fluor® 555)

Bindungsspezifität: pSer910

Kreuzreaktivität: Maus, Ratte, Xenopus laevis

Homologie: Human,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PTK2 around the phosphorylation site of Tyr910

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FAK

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Andere Bezeichnung: FAK

Hintergrund:

Synonyms: FAK phospho S910, p-FAK phospho S910, FADK 1, FADK, FAK 1, FAK related non kinase polypeptide, FAK1, Focal adhesion kinase 1, FRNK, pp125FAK, Protein tyrosine kinase 2, Protein Tyrosine Kinase Cytoplasmic, PTK 2, FAK1_HUMAN, Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK.

Background: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Gen-ID: 5747

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling