APC Antikörper (AA 2544-2843)

Produktnummer ABIN1678690

Dieses Anti-APC-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von APC in WB und IHC. Geeignet für Human.

Kurzübersicht für APC Antikörper (AA 2544-2843) (ABIN1678690)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-APC Antikörper

Bindungsspezifität: AA 2544-2843

Sequenz: SGTWKREHSK HSSSLPRVST WRRTGSSSSI LSASSESSEK AKSEDEKHVN SISGTKQSKE NQVSAKGTWR KIKENEFSPT NSTSQTVSSG ATNGAESKTL IYQMAPAVSK TEDVWVRIED CPINNPRSGR SPTGNTPPVI DSVSEKANPN IKDSKDNQAK QNVGNGSVPM RTVGLENRLN SFIQVDAPDQ KGTEIKPGQN NPVPVSETNE SSIVERTPFS SSSSSKHSSP SGTVAARVTP FNYNPSPRKS SADSTSARPS QIPTPVNNNT KKRDSKTDST ESSGTQSPKR HSGSYLVTSV

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2544-2843 of human APC (NP_000029.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: APC

Hintergrund: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.,APC,BTPS2,DP2,DP2.5,DP3,GS,PPP1R46,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Centrosome,Cell Adhesion,Microtubules,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Cell Type Marker,Stem Cells,Cardiovascular,Heart,Cardiogenesis,Oligodendrocyte marker,APC

Molekulargewicht: 300 kDa/311 kDa

Gen-ID: 324

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization