IgD Antikörper (N-Term)

Produktnummer ABIN1539994

Produktdetails anti-IgD Antikörper

Target: IgD

Bindungsspezifität: AA 37-64, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IgD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This IGHD antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-64 amino acids from the N-terminal region of human IGHD.

Klon: 607CT8-4-4

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:100~800

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: IGHD Antibody (N-term)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu IgD

Target: IgD

Andere Bezeichnung: IGHD (IgD Produkte)

Synonyme: IgD antikoerper, Igh-5 antikoerper, immunoglobulin heavy constant delta antikoerper, immunoglobulin delta heavy chain constant region antikoerper, Ighd antikoerper, Igd antikoerper, IGHD antikoerper

Substanzklasse: Antibody

Hintergrund: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Molekulargewicht: 42353

Gen-ID: 3495

UniProt: P01880