SPTAN1 Antikörper (Cleaved-Asp1185)

Produktnummer ABIN1536099

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SPTAN1 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SPTAN1 Antikörper (Cleaved-Asp1185) (ABIN1536099)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SPTAN1 Antikörper

Bindungsspezifität: AA 1136-1185, Cleaved-Asp1185

Verwendungszweck: Cleaved-Spectrin α II (D1185) Antibody

Spezifität: Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: SPTA2

Hintergrund:

Synonyms: SPTAN1, NEAS, SPTA2, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit

Background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement.This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

Gene Name: SPTAN1

Protein Name: Spectrin alpha chain non-erythrocytic 1

Molekulargewicht: 137 kDa

Gen-ID: 6709

OMIM: 182810

UniProt: Q13813

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization