Neurexin 1 Antikörper (AA 502-551)

Produktnummer ABIN1535088

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Neurexin 1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Neurexin 1 Antikörper (AA 502-551) (ABIN1535088)

Target: Neurexin 1 (NRXN1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurexin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Neurexin 1 Antikörper

Bindungsspezifität: AA 502-551

Verwendungszweck: Neurexin I Antibody

Spezifität: Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Neurexin 1

Target: Neurexin 1 (NRXN1)

Andere Bezeichnung: NRXN1

Hintergrund:

Synonyms: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alpha

Background: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Gene Name: NRXN1

Protein Name: Neurexin-1-alpha

Molekulargewicht: 161 kDa

Gen-ID: 9378

OMIM: 600565

UniProt: Q9ULB1

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development