MUC16 Antikörper (AA 13311-13360)

Produktnummer ABIN1534035

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MUC16 in IHC und WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für MUC16 Antikörper (AA 13311-13360) (ABIN1534035)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC16 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-MUC16 Antikörper

Bindungsspezifität: AA 13311-13360

Verwendungszweck: Mucin 16 Antibody

Spezifität: Mucin 16 Polyclonal Antibody detects endogenous levels of Mucin 16 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MUC16. AA range:13311-13360

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: MUC16

Hintergrund:

Synonyms: MUC16, CA125, Mucin-16, MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125

Background: domain:Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.,function:Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.,induction:Up-regulated in ovarian cancer cells.,miscellaneous:Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.,polymorphism:The number of repeats is highly polymorphic.,PTM:Heavily N-glycosylated, expresses primarily high mannose and complex bisecting type N-linked glycans.,PTM:Heavily O-glycosylated, expresses both type 1 and type 2 core glycans.,PTM:May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.,PTM:May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.,similarity:Contains 14 LRR (leucine-rich) repeats.,similarity:Contains 2 ANK repeats.,similarity:Contains 56 SEA domains.,subcellular location:May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.,subunit:Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.,tissue specificity:Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.,

Gene Name: MUC16

Protein Name: Mucin-16

Molekulargewicht: 2353 kDa

Gen-ID: 94025

OMIM: 606154

UniProt: Q8WXI7