SKIL Antikörper (AA 616-665)

Produktnummer ABIN1533612

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SKIL in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für SKIL Antikörper (AA 616-665) (ABIN1533612)

Target: SKIL (SKI-Like Oncogene (SKIL))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SKIL Antikörper

Bindungsspezifität: AA 616-665

Verwendungszweck: SnoN Antibody

Spezifität: SnoN Polyclonal Antibody detects endogenous levels of SnoN protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu SKIL

Target: SKIL (SKI-Like Oncogene (SKIL))

Andere Bezeichnung: SKIL

Hintergrund:

Synonyms: SKIL, SNO, Ski-like protein, Ski-related oncogene, Ski-related protein

Background: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Gene Name: SKIL

Protein Name: Ski-like protein

Molekulargewicht: 77 kDa

Gen-ID: 6498

OMIM: 165340

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus