SKIL Antikörper (AA 590-670)

Produktnummer ABIN7217066

Der Kaninchen Polyklonal anti-SKIL Antikörper wird verwendet zum Nachweis von SKIL in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IHC und IF.

Kurzübersicht für SKIL Antikörper (AA 590-670) (ABIN7217066)

Target: SKIL (SKI-Like Oncogene (SKIL))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SKIL Antikörper

Bindungsspezifität: AA 590-670

Verwendungszweck: Rabbit Anti-SnoN Polyclonal Antibody

Spezifität: SnoN Polyclonal Antibody detects endogenous levels of SnoN protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human SnoN at AA range: 590-670

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu SKIL

Target: SKIL (SKI-Like Oncogene (SKIL))

Andere Bezeichnung: SnoN

Hintergrund: SKIL, SNO, Ski-like protein, Ski-related oncogene, Ski-related proteinSki-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Molekulargewicht: 77kD

Gen-ID: 6498

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus