SOCS3 Antikörper (AA 2-44)

Produktnummer ABIN1504156

Produktdetails anti-SOCS3 Antikörper

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Bindungsspezifität: AA 2-44

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: This antibody reacts with mouse SOCS-3.

Aufreinigung: Protein A agarose

Klon: 1B2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3 / CIS3 (SOCS3 Produkte)

Synonyme: socs3 antikoerper, fj09e12 antikoerper, zgc:56537 antikoerper, wu:fj09e12 antikoerper, MGC64393 antikoerper, MGC75749 antikoerper, xsocs3 antikoerper, MGC81248 antikoerper, atod4 antikoerper, cis3 antikoerper, cish3 antikoerper, socs-3 antikoerper, ssi-3 antikoerper, ssi3 antikoerper, SOCS3 antikoerper, ATOD4 antikoerper, CIS3 antikoerper, Cish3 antikoerper, SOCS-3 antikoerper, SSI-3 antikoerper, SSI3 antikoerper, Cis3 antikoerper, EF-10 antikoerper, Ef10 antikoerper, Ssi3 antikoerper, Socs-3 antikoerper, Ssi-3 antikoerper, suppressor of cytokine signaling 3a antikoerper, suppressor of cytokine signaling 3 S homeolog antikoerper, suppressor of cytokine signaling 3 antikoerper, suppressor of cytokine signaling 3 L homeolog antikoerper, socs3a antikoerper, socs3.S antikoerper, socs3 antikoerper, socs3.L antikoerper, SOCS3 antikoerper, Socs3 antikoerper

Hintergrund: The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction. Socs genes are induced by cytokines to express SOCS proteins, which then inhibit cytokine-induced signaling. SOCS-3, also known as CIS3 or SSI3, inhibits cytokine signaling by multiple cytokines and hormones, including Epo, prolactin, growth hormone (GH), IL-2, IL-3, IL-6, IL-11, leptin, ciliary neurotrophic factor, MCSF, and LIF. The SH2 domain of SOCS-3 also interacts with the cytoplasmic domains of phosphorylated GH receptor, leptin receptor, IGF-I receptor, and the gp130 common receptor subunit. SOCS-3 directly inhibits JAK2 catalytic activity, and silencing of SOCS-3 by methylation may be an important mechanism of constitutive activation of the JAK/STAT pathway in cancer pathogenesis.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3

Gen-ID: 9021

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C