SOCS3 Antikörper (Middle Region)

Produktnummer ABIN3044272

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SOCS3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Maus. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für SOCS3 Antikörper (Middle Region) (ABIN3044272)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SOCS3 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-SOCS3 Antibody

Sequenz: RDSSDQRHFF TLSVK

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse sequence,different from the related rat sequence by one amino acid.

Produktmerkmale: Anti-SOCS3 Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human SOCS3, identical to the related mouse sequence, different from the related rat sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, MouseWestern blot, 0.1-0.5 μg/mL, Human, Mouse

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SOCS3 Antikörper (ABIN3044272)

Yang, Tian, Zhang, Xu, Yang, Yu, Li, Li, Li, Li: "Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications." in: Oncotarget, Vol. 8, Issue 57, pp. 96958-96969, (2017) (PubMed).

Wan, Che, Kang, Wu: "SOCS3 blocks HIF-1? expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3." in: Molecular medicine reports, Vol. 12, Issue 1, pp. 83-92, (2015) (PubMed).

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3

Hintergrund:

Background: SOCS3 (Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene. SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Gene Full Name: suppressor of cytokine signaling 3

Sequence Similarities: Contains 1 SH2 domain.

Molekulargewicht: 30 kDa

Gen-ID: 9021

UniProt: O14543

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C