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SOCS3 Antikörper (AA 2-44)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SOCS3 in WB und IP. Er zeigt eine Reaktivität gegenüber Maus.
Produktnummer ABIN1504156

Kurzübersicht für SOCS3 Antikörper (AA 2-44) (ABIN1504156)

Target

Alle SOCS3 Antikörper anzeigen
SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität

  • 56
  • 36
  • 34
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Maus

Wirt

  • 65
  • 22
Maus

Klonalität

  • 66
  • 21
Monoklonal

Konjugat

  • 52
  • 12
  • 8
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser SOCS3 Antikörper ist unkonjugiert

Applikation

  • 58
  • 35
  • 31
  • 18
  • 13
  • 11
  • 6
  • 6
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP)

Klon

1B2
  • Bindungsspezifität

    • 23
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-44

    Spezifität

    This antibody reacts with mouse SOCS-3.

    Aufreinigung

    Protein A agarose

    Isotyp

    IgG1
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

    Konservierungsmittel

    Without preservative
  • Target

    SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

    Andere Bezeichnung

    SOCS3 / CIS3

    Hintergrund

    The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction. Socs genes are induced by cytokines to express SOCS proteins, which then inhibit cytokine-induced signaling. SOCS-3, also known as CIS3 or SSI3, inhibits cytokine signaling by multiple cytokines and hormones, including Epo, prolactin, growth hormone (GH), IL-2, IL-3, IL-6, IL-11, leptin, ciliary neurotrophic factor, MCSF, and LIF. The SH2 domain of SOCS-3 also interacts with the cytoplasmic domains of phosphorylated GH receptor, leptin receptor, IGF-I receptor, and the gp130 common receptor subunit. SOCS-3 directly inhibits JAK2 catalytic activity, and silencing of SOCS-3 by methylation may be an important mechanism of constitutive activation of the JAK/STAT pathway in cancer pathogenesis.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3

    Gen-ID

    9021

    Pathways

    JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C
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