GCK Antikörper (AA 43-92)

Produktnummer ABIN1453323

Der Kaninchen Polyklonal anti-GCK Antikörper (ABIN1453323) detektiert spezifisch GCK in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für GCK Antikörper (AA 43-92) (ABIN1453323)

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GCK Antikörper

Bindungsspezifität: AA 43-92

Verwendungszweck: GCK Antibody

Spezifität: GCK Polyclonal Antibody detects endogenous levels of GCK protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human GCK. AA range:43-92

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu GCK

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Andere Bezeichnung: GCK

Hintergrund:

Synonyms: GCK, Glucokinase, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009],

Gene Name: GCK

Protein Name: Glucokinase

Molekulargewicht: 52 kDa

Gen-ID: 2645

OMIM: 138079

UniProt: P35557

Pathways: MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process