PRICKLE1 Antikörper (C-Term)

Produktnummer ABIN1450074

Dieses Anti-PRICKLE1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRICKLE1 in WB, IF und EIA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für PRICKLE1 Antikörper (C-Term) (ABIN1450074)

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRICKLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-PRICKLE1 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PRICKLE1

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Andere Bezeichnung: PRICKLE1

Hintergrund: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.Synonyms: PRICKLE-1, Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, RILP

Gen-ID: 144165

NCBI Accession: NP_694571

Pathways: WNT Signalweg, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus