Retinoblastoma 1 Antikörper (pThr821)

Produktnummer ABIN1449258

Dieses Anti-Retinoblastoma 1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Retinoblastoma 1 in WB. Geeignet für Human.

Kurzübersicht für Retinoblastoma 1 Antikörper (pThr821) (ABIN1449258)

Target: Retinoblastoma 1 (RB1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 24A7

Produktdetails anti-Retinoblastoma 1 Antikörper

Bindungsspezifität: pThr821

Spezifität: This antibody specifically recognizes human Rb with phosphorylated at Thr821.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Andere Bezeichnung: Retinoblastoma-Associated Protein / RB1

Hintergrund: Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G 1 phase and halting inappropriate cell proliferation (Ref1 . At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU.1, ATF2, UBF, Elf-1 and c-Abl (Ref 2-4 . Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhibit the transcription and the cell cycle progression is inactivated by phosphorylation, which is catalyzed by the cyclin-d ependent protein kinases.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

Gen-ID: 5925

NCBI Accession: NP_000312

UniProt: P06400

Pathways: Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie