SF3B1 Antikörper

Produktnummer ABIN1449178

Produktdetails anti-SF3B1 Antikörper

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Reaktivität: Human, Maus, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SF3B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts with Sap155.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Hamster

Aufreinigung: Protein A agarose

Immunogen: Recombinant mouse Sap155

Klon: 1A5

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SF3B1

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Andere Bezeichnung: SF3B1 / SAP155 (SF3B1 Produkte)

Synonyme: Cus1 antikoerper, SAP145 antikoerper, SF3B145 antikoerper, SF3b1 antikoerper, SF3b150 antikoerper, Hsh155 antikoerper, MDS antikoerper, PRP10 antikoerper, PRPF10 antikoerper, SAP155 antikoerper, SF3b155 antikoerper, 155kDa antikoerper, 2810001M05Rik antikoerper, AA409119 antikoerper, Prp10 antikoerper, TA-8 antikoerper, Targ4 antikoerper, hsh155 antikoerper, prp10 antikoerper, prpf10 antikoerper, sap155 antikoerper, SF3B1 antikoerper, Sap155 antikoerper, wu:fb99f09 antikoerper, splicing factor 3b subunit 2 antikoerper, splicing factor 3b subunit 1 antikoerper, splicing factor 3b, subunit 1 antikoerper, splicing factor 3b subunit 1 S homeolog antikoerper, SF3B2 antikoerper, SF3B1 antikoerper, Sf3b1 antikoerper, sf3b1.S antikoerper, sf3b1 antikoerper

Hintergrund: SF3 is a U2 snRNP-associated protein complex essential for spliceosome assembly and splicing catalysis of the major spliceosome. SF3 contains the Spliceosome-Associated Proteins, SAP 49, 130, 145, and 155. SAP155/Sf3b1 is an essential subunit of the U2 snRNP for mRNA splicing and has also been identified in the minor (U12-dependent) spliceosome. SAP155 interacts with the mammalian PcG (Polycomb group) proteins, Mel18 and Ring1B by the yeast two-hybrid system. SAP155 contains numerous Cdk consensus phosphorylation sites in its N terminus and is phosphorylated prior to catalytic step II of the splicing pathway. SAP155 serves as a substrate for cyclin E-cdk2 in vitro, suggesting that pre-mRNA splicing may be linked to the cell cycle machinery in mammalian cells.Synonyms: Pre-mRNA-splicing factor SF3b 155 kDa subunit, SAP 155, SAP-155, SF3b155, Spliceosome-associated protein 155, Splicing factor 3B subunit 1

Gen-ID: 23451

NCBI Accession: NP_036565

UniProt: O75533

Pathways: Chromatin Binding