CCR5 Antikörper

Produktnummer ABIN1449163

Dieser Ratte Monoklonal Antikörper erkennt spezifisch CCR5 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CCR5 Antikörper (ABIN1449163)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CCR5 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: T227

Produktdetails anti-CCR5 Antikörper

Spezifität: This antibody reacts with CD195 antigen.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Ammonium sulfate precipitation followed by gel filtration through Superdex 200 in PBS

Immunogen: Syngeneic human CD195 transfectants

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Andere Bezeichnung: CD195 / CCR5

Hintergrund: CD195/CCR5, is a seven transmembrane receptor that is a member of the ß-chemokine receptor family. CCR5 is expressed by T cells and macrophages, and is one of the two major co-receptors for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with resistance to HIV infection, and early infection with HIV-1 is dominated by CCR5-tropic viruses. The ligands of the CCR5 receptor include MCP-2, MIP-1a, MIP-1ß, and RANTES. CCR5 is phosphorylated at specific sites by protein kinase C and GPCR kinase, and data show that two distinct forms of CCR5 protein, 62 and 42 kDa, are present in lymphocytic cells. CCR5 expression was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor

Gen-ID: 1234

NCBI Accession: NP_000570

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size