CADPS Antikörper (AA 151-250) (HRP)

Produktnummer ABIN1411364

Der Kaninchen Polyklonal Anti-CADPS-Antikörper wurde für IHC (fro) validiert. Er ist geeignet, CADPS in Proben von Human zu detektieren.

Kurzübersicht für CADPS Antikörper (AA 151-250) (HRP) (ABIN1411364)

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CADPS Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CADPS Antikörper (HRP)

Bindungsspezifität: AA 151-250

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CAPS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CADPS

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Andere Bezeichnung: CAPS1

Hintergrund:

Synonyms: Cadps, CADPS1, Calcium dependent secretion activator 1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, Caps, CAPS-1, rCAPS, CAPS1_HUMAN.

Background: Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism.

Pathways: Synaptic Vesicle Exocytosis