CADPS Antikörper (C-Term)

Produktnummer ABIN499523

Der Kaninchen Polyklonal anti-CADPS Antikörper wird verwendet zum Nachweis von CADPS in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für CADPS Antikörper (C-Term) (ABIN499523)

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CADPS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CADPS Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to CAPS1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CAPS1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human CAPS1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CAPS1 antibody can be used for detection of CAPS1 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CADPS

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Andere Bezeichnung: CADPS

Hintergrund: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles, CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion. Numerous isoforms of CAPS1 are known to exist, the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.Synonyms: CAPS, CAPS-1, CAPS1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, KIAA1121

Gen-ID: 8618

NCBI Accession: NP_899631

UniProt: Q9ULU8

Pathways: Synaptic Vesicle Exocytosis