CHMP2B Antikörper (AA 31-120) (Cy5.5)

Produktnummer ABIN1410785

Der Kaninchen Polyklonal Anti-CHMP2B-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, CHMP2B in Proben von Maus zu detektieren.

Kurzübersicht für CHMP2B Antikörper (AA 31-120) (Cy5.5) (ABIN1410785)

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP2B Antikörper ist konjugiert mit Cy5.5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-CHMP2B Antikörper (Cy5.5)

Bindungsspezifität: AA 31-120

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CHMP2B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CHMP2B

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Andere Bezeichnung: CHMP2B

Hintergrund:

Synonyms: Charged multivesicular body protein 2b, CHM2B_HUMAN, CHMP2.5, CHMP2b, Chromatin modying protein 2b, Chromatin-modying protein 2b, DMT1, hVps2-2, Vacuolar protein sorting 2-2, VPS2 homolog B, Vacuolar protein sorting-associated protein 2-2, Vps2-2, VPS2B.

Background: The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B, also known as CHMP2.5 or vacuolar protein-sorting-associated protein 2-2, is a 213 amino acid cytosolic protein. Widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes, CHMP2B associates directly with CHMP2A and vps4 for the disassembly of the ESCRT-III complex. Defects in the gene encoding CHMP2B have been shown to cause chromosome 3-linked frontotemporal dementia (FTD3).