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DISP2 Antikörper (AA 1101-1200) (Cy5)

DISP2 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy5
Produktnummer ABIN1410052
  • Target Alle DISP2 Antikörper anzeigen
    DISP2 (Dispatched Homolog 2 (DISP2))
    Bindungsspezifität
    • 14
    • 2
    • 2
    • 1
    • 1
    AA 1101-1200
    Reaktivität
    • 18
    • 2
    • 2
    Human
    Wirt
    • 18
    Kaninchen
    Klonalität
    • 18
    Polyklonal
    Konjugat
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DISP2 Antikörper ist konjugiert mit Cy5
    Applikation
    • 12
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DISP2
    Isotyp
    IgG
    Top Product
    Discover our top product DISP2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DISP2 (Dispatched Homolog 2 (DISP2))
    Andere Bezeichnung
    DISP2 (DISP2 Produkte)
    Synonyme
    DISP2 antikoerper, DISPB antikoerper, HsT16908 antikoerper, AI840597 antikoerper, B230210L08Rik antikoerper, DispB antikoerper, mKIAA1742 antikoerper, dispatched RND transporter family member 2 antikoerper, dispatched RND tramsporter family member 2 antikoerper, dispatched homolog 2 (Drosophila) antikoerper, DISP2 antikoerper, Disp2 antikoerper
    Hintergrund

    Synonyms: DISPB, HsT16908, Protein dispatched homolog 2, DISP2, KIAA1742

    Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.

    Gen-ID
    85455
    UniProt
    A7MBM2
    Pathways
    Hedgehog Signalweg
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