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DISP2 Antikörper (N-Term)

DISP2 Reaktivität: Human ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991015
  • Target Alle DISP2 Antikörper anzeigen
    DISP2 (Dispatched Homolog 2 (DISP2))
    Bindungsspezifität
    • 15
    • 2
    • 1
    • 1
    AA 110-160, N-Term
    Reaktivität
    • 18
    • 2
    • 2
    Human
    Wirt
    • 18
    Kaninchen
    Klonalität
    • 18
    Polyklonal
    Konjugat
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DISP2 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.
    Aufreinigung
    DISP2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2. The immunogen is located within amino acids 110 - 160 of DISP2.
    Isotyp
    IgG
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  • Applikationshinweise
    DISP2 antibody can be used for detection of DISP2 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    DISP2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    DISP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    DISP2 (Dispatched Homolog 2 (DISP2))
    Andere Bezeichnung
    DISP2 (DISP2 Produkte)
    Synonyme
    DISP2 antikoerper, DISPB antikoerper, HsT16908 antikoerper, AI840597 antikoerper, B230210L08Rik antikoerper, DispB antikoerper, mKIAA1742 antikoerper, dispatched RND transporter family member 2 antikoerper, dispatched RND tramsporter family member 2 antikoerper, dispatched homolog 2 (Drosophila) antikoerper, DISP2 antikoerper, Disp2 antikoerper
    Hintergrund
    DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.
    Gen-ID
    85455
    UniProt
    A7MBM2
    Pathways
    Hedgehog Signalweg
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