ERN1 Antikörper (AA 252-260) (FITC)
Kurzübersicht für ERN1 Antikörper (AA 252-260) (FITC) (ABIN1400144)
Target
Alle ERN1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 252-260
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Kreuzreaktivität
- Human, Maus, Schwein, Ratte
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Homologie
- Dog,Cow,Horse,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human IRE1a
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Isotyp
- IgG
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Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).
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: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).
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- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
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Andere Bezeichnung
- IRE1a
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Hintergrund
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Synonyms: IRE1, IRE1P, IRE1a, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, ERN1
Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
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Gen-ID
- 2081
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UniProt
- O75460
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Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
Target
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