CHEK2 Antikörper (AA 101-200) (AbBy Fluor® 555)
Kurzübersicht für CHEK2 Antikörper (AA 101-200) (AbBy Fluor® 555) (ABIN1393349)
Target
Alle CHEK2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 101-200
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Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human Rad53/SPK1
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Isotyp
- IgG
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anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibodyCHEK2 Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB19067 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IP, IHC (p), FACS Wirt: Maus Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IF, IP, IHC (p), FACS Wirt: Maus Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Affe, Hund WB, IHC, IF, IHC (p), FACS Wirt: Maus Monoclonal 10G7 unconjugated
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Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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Andere Bezeichnung
- Rad53/SPK1
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Hintergrund
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Synonyms: CHEK2 homolog, CHK2 homolog, MEC2, RAD53, RAD53_YEAST, Serine protein kinase 1, Serine-protein kinase 1, Serine/threonine-protein kinase RAD53, SPK1.
Background: DNA damage results in the arrest of cell cycle progression, allowing the damaged DNA to be repaired prior to replication. Checkpoints exist at several cell cycle phase transitions to maintain this genetic integrity. Rad9, Rad17, Rad24 and Mec3 are involved in activating the G1 and G2 checkpoints (14). Pol2 (also known as Dun2), encoding the catalytic subunit of DNA polymerase epsilon, plays a role in activating the S phase checkpoint (5). The protein kinase Rad53 (also designated Spk1, Mec2 or Sad1) is essential for both G2 and S phase arrest. Activation of Rad53 is regulated by Mec1 (also known as Esr1 and Sad3), a homolog of the human ATM protein (6). Pds1 and Mad2 both regulate checkpoints associated with incomplete spindle replication (7,8). Dun1, another protein kinase, plays a role in transducing the DNA damage signal (9).
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Pathways
- p53 Signalweg, Apoptose, Zellzyklus
Target
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