ATM Antikörper (pTyr170) (AbBy Fluor® 555)

Produktnummer ABIN1392863

Der Kaninchen Polyklonal Anti-ATM-Antikörper wurde für IF (p) validiert. Er ist geeignet, ATM in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ATM Antikörper (pTyr170) (AbBy Fluor® 555) (ABIN1392863)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATM Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-ATM Antikörper (AbBy Fluor® 555)

Bindungsspezifität: pTyr170

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ATM around the phosphorylation site of Tyr170 [SV(p-Y)FR]

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: ATM

Hintergrund:

Synonyms: ATM Tyr170, ATM Y170, p-ATM Tyr170, p-ATM Y170, A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog human, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM_HUMAN, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, T cell prolymphocytic leukemia, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein, TPLL.

Background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).

Molekulargewicht: 370kDa

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus