Presenilin 1 Antikörper (AA 321-430) (Biotin)

Produktnummer ABIN1392709

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Presenilin 1 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für Presenilin 1 Antikörper (AA 321-430) (Biotin) (ABIN1392709)

Target: Presenilin 1 (PSEN1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Presenilin 1 Antikörper (Biotin)

Bindungsspezifität: AA 321-430

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Presenilin-1/ Presenilin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Presenilin 1

Target: Presenilin 1 (PSEN1)

Andere Bezeichnung: Presenilin 1

Hintergrund:

Synonyms: AD 3, AD4, AD5, Alzheimer disease 3, Alzheimer disease 4, FAD, Presenilin 1, Presenilin 2, Presenilin-1, Presenilin-2, Presenilin1, Presenilin1, PS1, PS2, PS-1, PS-2, PSEN1, PSEN2, STM2, PSN1_HUMAN, PSN2_HUMAN.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.

Pathways: Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport