Presenilin 1 Antikörper (AA 321-430) (AbBy Fluor® 555)

Produktnummer ABIN1392707

Der Kaninchen Polyklonal Anti-Presenilin 1-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, Presenilin 1 in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für Presenilin 1 Antikörper (AA 321-430) (AbBy Fluor® 555) (ABIN1392707)

Target: Presenilin 1 (PSEN1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 1 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Presenilin 1 Antikörper (AbBy Fluor® 555)

Bindungsspezifität: AA 321-430

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Presenilin-1/ Presenilin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Presenilin 1

Target: Presenilin 1 (PSEN1)

Andere Bezeichnung: Presenilin 1

Hintergrund:

Synonyms: AD 3, AD4, AD5, Alzheimer disease 3, Alzheimer disease 4, FAD, Presenilin 1, Presenilin 2, Presenilin-1, Presenilin-2, Presenilin1, Presenilin1, PS1, PS2, PS-1, PS-2, PSEN1, PSEN2, STM2, PSN1_HUMAN, PSN2_HUMAN.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.

Pathways: Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport