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GLIS2 Antikörper (AA 271-350) (FITC)

This anti-GLIS2 antibody (ABIN1392032) is a Rabbit Polyclonal antibody detecting GLIS2 in WB, IF (cc), IF (p). Suitable for Mouse, Rat.
Produktnummer ABIN1392032

Kurzübersicht für GLIS2 Antikörper (AA 271-350) (FITC) (ABIN1392032)

Target

Alle GLIS2 Antikörper anzeigen
GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reaktivität

  • 20
  • 18
  • 18
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 34
Kaninchen

Klonalität

  • 34
Polyklonal

Konjugat

  • 13
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GLIS2 Antikörper ist konjugiert mit FITC

Applikation

  • 29
  • 16
  • 12
  • 12
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 271-350

    Kreuzreaktivität

    Maus, Ratte

    Homologie

    Human,Dog,Cow,Sheep,Pig,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GLIS2

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

    Andere Bezeichnung

    GLIS2

    Hintergrund

    Synonyms: NPHP7, NKL, GLI kruppel family member 2, GLI similar 2, GLI-similar 2, GLIS 2, GLIS family zinc finger 2, glis2, GLIS2_HUMAN, Kruppel like zinc finger protein GLIS2, Neuronal Krueppel-like protein, Tax helper protein, THP, Zinc finger protein GLI2, Zinc finger protein GLIS2.

    Background: GLIS2 is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family. By recruiting the corepressors CtBP1 and HDAC3, GLIS2 represses the transcriptional activation mediated by a??-catenin in the Wnt pathway. GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation. Mutations of GLIS2 may be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis. GLIS2 contains five tandem Cys(2)-His(2) zinc finger motifs that exhibit the highest homology to those of members of the GLI and Zic subfamilies of Kr??ppel-like proteins. GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta.

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