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MSH3 Antikörper (AA 521-620)

Dieses Anti-MSH3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MSH3 in WB, IHC (p) und IHC (fro). Geeignet für Human, Maus und Ratte.
Produktnummer ABIN1387851

Kurzübersicht für MSH3 Antikörper (AA 521-620) (ABIN1387851)

Target

Alle MSH3 Antikörper anzeigen
MSH3 (MutS Homolog 3 (MSH3))

Reaktivität

Human, Maus, Ratte

Wirt

  • 27
  • 1
Kaninchen

Klonalität

  • 27
  • 1
Polyklonal

Konjugat

  • 14
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MSH3 Antikörper ist unkonjugiert

Applikation

  • 13
  • 13
  • 12
  • 9
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 521-620

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Cow,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MSH3

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MSH3 (MutS Homolog 3 (MSH3))

    Andere Bezeichnung

    MSH3

    Hintergrund

    Synonyms: DUP, MRP1, DNA mismatch repair protein Msh3, hMSH3, Divergent upstream protein, Mismatch repair protein 1, MSH3, DUC1, DUG

    Background: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

    Gen-ID

    4437

    UniProt

    P20585

    Pathways

    DNA Reparatur, Production of Molecular Mediator of Immune Response
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