MYBPC3 Antikörper

Produktnummer ABIN1387208

Der Kaninchen Polyklonal Anti-MYBPC3-Antikörper wurde für WB, IF (p) und IHC (p) validiert. Er ist geeignet, MYBPC3 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für MYBPC3 Antikörper (ABIN1387208)

Target: MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYBPC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MYBPC3 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYBPC3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MYBPC3

Target: MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

Andere Bezeichnung: MYBPC3

Hintergrund:

Synonyms: C protein cardiac muscle isoform, cardiac muscle isoform, cardiac-type, C-protein, Cardiac MyBP C, Cardiac MyBP-C, Cardiac myosin binding protein C, MYBP C, MYBPC, MYBPC3, Myosin binding protein C cardiac, Myosin binding protein C cardiac-type, Myosin-binding protein C, MYPC3_HUMAN.

Background: MYBPC3 encodes the cardiac isoform of the thick-filament myosin-binding protein C. It is found in the crossbridge-bearing zone (C region) of A bands in vertebrate striated muscle. Regulatory phosphorylation of MYBPC3 by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. MYBPC3 binds F-Actin, MHC and native thin filaments, and modifies the activity of Actin-activated myosin ATPase. Mutations in the MYBPC3 gene lead mainly to truncation of the protein, which results in one cause of familial hypertrophic cardiomyopathy type 4 (CMH4), a heart disorder characterized by ventricular hypertrophy, which often involves the interventricular septum and is usually asymmetric. The MYBPC3 gene maps to chromosome 11p11.2.

Gen-ID: 4607