PSMA7 Antikörper

Produktnummer ABIN1387047

Produktdetails anti-PSMA7 Antikörper

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMA7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Proteasome 20S alpha 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PSMA7

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Abstract: PSMA7 Produkte

Synonyme: C6 antikoerper, HSPC antikoerper, RC6-1 antikoerper, XAPC7 antikoerper, C6-I antikoerper, DDBDRAFT_0185059 antikoerper, DDBDRAFT_0217080 antikoerper, DDB_0185059 antikoerper, DDB_0217080 antikoerper, hspc antikoerper, rc6-1 antikoerper, xapc7 antikoerper, psma7 antikoerper, psma4-B antikoerper, proteasome subunit alpha 7 antikoerper, proteasome (prosome, macropain) subunit, alpha type 7 antikoerper, 20S proteasome subunit alpha-7 antikoerper, proteasome subunit alpha 7 S homeolog antikoerper, proteasome subunit alpha 7 L homeolog antikoerper, PSMA7 antikoerper, Psma7 antikoerper, psmA7 antikoerper, psma7 antikoerper, psma7.S antikoerper, psma7.L antikoerper

Hintergrund:

Synonyms: C6 antibody HSPC, Proteasome prosome macropain subunit alpha type 7, Proteasome alpha 7 subunit, Proteasome subunit alpha 4, Proteasome subunit alpha type 7, Proteasome subunit alpha type-7, Proteasome subunit RC6 1, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSA7_HUMAN, PSMA7, RC6 1, XAPC7.

Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gen-ID: 5688

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA