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SPPL2B Antikörper (AA 55-135)

Dieses Anti-SPPL2B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SPPL2B in WB, ELISA, IHC (p), ICC, IF (cc), IF (p) und IHC (fro). Geeignet für Human.
Produktnummer ABIN1386177

Kurzübersicht für SPPL2B Antikörper (AA 55-135) (ABIN1386177)

Target

Alle SPPL2B Antikörper anzeigen
SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reaktivität

  • 11
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 11
Kaninchen

Klonalität

  • 11
Polyklonal

Konjugat

  • 8
  • 1
  • 1
  • 1
Dieser SPPL2B Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 55-135

    Homologie

    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human SPPL2B

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

    Andere Bezeichnung

    IMP4/SPPL2B

    Hintergrund

    Synonyms: IMP4, Signal peptide peptidase-like 2B, Intramembrane protease 4, Protein SPP-like 2B, SPPL2B, SPP2B_HUMAN.

    Background: SPPL2b is a 592 amino acid multi-pass membrane protein that contains one protease associated domain and belongs to the GXGD family of aspartic proteases. Localized to the membrane of the Golgi apparatus and to lysosomes, endosomes and the plasma membrane, SPPL2b functions as an intramembrane protease that specifically cleaves the transmembrane domain of TNF? Once cleaved, TNF?releases its intracellular domain, thus triggering the immunity-related expression of cytokines (also known as interleukins) which are used in various pathways throughout the body. SPPL2b also interacts with and catalyzes the intramembrane proteolysis of ITM2B (integral membrane protein 2B), a protein that, when mutated, is associated with dementia. Four isoforms of SPPL2b exist due to alternative splicing events.

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