SPPL2B Antikörper (N-Term)

Produktnummer ABIN2782090

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SPPL2B in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Rind (Kuh), Maus, Pferd, Schwein, Hund und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SPPL2B Antikörper (N-Term) (ABIN2782090)

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reaktivität: Human, Ratte, Rind (Kuh), Maus, Pferd, Schwein, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPPL2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SPPL2B Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SPPL2B Antibody - N-terminal region

Sequenz: VARGNCTFYE KVRLAQGSGA RGLLIVSRER LVPPGGNKTQ YDEIGIPVAL

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against SPPL2B. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPPL2B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44989-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SPPL2B Antikörper (ABIN2782090)

Del Campo, Hoozemans, Dekkers, Rozemuller, Korth, Müller-Schiffmann, Scheltens, Blankenstein, Jimenez, Veerhuis, Teunissen: "BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease." in: Neurobiology of aging, Vol. 35, Issue 7, pp. 1596-604, (2014) (PubMed).

Details zu SPPL2B

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Andere Bezeichnung: SPPL2B

Hintergrund:

Background Information: SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

Gene Name: Signal peptide peptidase like 2B

Alternative Symbols: IMP4, PSH4, PSL1, IMP-4

Protein Name: Signal peptide peptidase-like 2B

Molekulargewicht: 56kDa

Gen-ID: 56928

NCBI Accession: NP_001070706

UniProt: Q8TCT7