GABRE Antikörper (AA 54-150)

Produktnummer ABIN1386029

Der Kaninchen Polyklonal Anti-GABRE Antikörper wurde für ELISA, IF (cc), IF (p), ICC, IHC (p) und IHC (fro) validiert. Er ist geeignet, GABRE in Proben von Human zu detektieren.

Kurzübersicht für GABRE Antikörper (AA 54-150) (ABIN1386029)

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRE Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GABRE Antikörper

Bindungsspezifität: AA 54-150

Homologie: Human,Mouse,Rat,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABARE/GABA Receptor Epsilon

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GABRE

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Andere Bezeichnung: GABARE/GABA Receptor Epsilon

Hintergrund:

Synonyms: GABAA receptor epsilon, GABAA receptor subunit epsilon, Gabre, Gamma aminobutyric acid GABA A receptor epsilon, Gamma aminobutyric acid receptor subunit epsilon, Gamma-aminobutyric acid receptor subunit epsilon, GBRE_HUMAN.

Background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R Alpha 1-6, GABAA R Beta 1-3, GABAA R Gamma 1-3, GABAA R Delta, GABAA R Epsilon, GABAA R Zeta 1 and GABAA R Zeta 2. The GABAB family is composed of GABAB R1 Alpha and GABAB R1 Beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

Pathways: Synaptic Membrane