GABRE Antikörper (Middle Region)

Produktnummer ABIN2776248

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GABRE in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Meerschweinchen und Kaninchen. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für GABRE Antikörper (Middle Region) (ABIN2776248)

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GABRE Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: GABRE Antibody - middle region

Sequenz: KNSWKLFQFD FTGVSNKTEI ITTPVGDFMV MTIFFNVSRR FGYVAFQNYV

Homologie: Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 86%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against GABRE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GABRE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101279

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GABRE Antikörper (ABIN2776248)

Fatemi, Folsom, Rooney, Thuras: "Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder." in: Translational psychiatry, Vol. 3, pp. e303, (2013) (PubMed).

Hengen, Nelson, Stang, Johnson, Crader, Watters, Mitchell, Behan: "Increased GABA(A) receptor ?-subunit expression on ventral respiratory column neurons protects breathing during pregnancy." in: PLoS ONE, Vol. 7, Issue 1, pp. e30608, (2012) (PubMed).

Hengen, Gomez, Stang, Johnson, Behan: "Changes in ventral respiratory column GABAaR ?- and ?-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 2, pp. R272-83, (2011) (PubMed).

Details zu GABRE

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Andere Bezeichnung: GABRE

Hintergrund:

Targeted Subunit: epsilon

Background Information: GABRE belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: Gamma-aminobutyric acid (GABA) A receptor, epsilon

Molekulargewicht: 43kDa

Gen-ID: 2564

NCBI Accession: NP_068819

UniProt: P78334

Pathways: Synaptic Membrane