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Influenza Nucleoprotein Antikörper (Influenza A Virus (A/Russia:St.Petersburg/8/2006)) (AA 71-170)

Der Kaninchen Polyklonal Anti--Antikörper wurde für WB, IHC (fro) und IHC (p) validiert. Er ist geeignet, in Proben von Influenza A Virus und Virus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN1385576

Kurzübersicht für Influenza Nucleoprotein Antikörper (Influenza A Virus (A/Russia:St.Petersburg/8/2006)) (AA 71-170) (ABIN1385576)

Target

Alle Influenza Nucleoprotein (NP) Antikörper anzeigen
Influenza Nucleoprotein (NP)

Reaktivität

  • 60
  • 40
  • 15
  • 14
  • 6
  • 4
  • 2
  • 1
  • 1
Influenza A Virus, Virus

Wirt

  • 72
  • 51
  • 4
Kaninchen

Klonalität

  • 74
  • 52
Polyklonal

Konjugat

  • 85
  • 12
  • 9
  • 8
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Unkonjugiert

Applikation

  • 87
  • 71
  • 23
  • 14
  • 12
  • 11
  • 9
  • 9
  • 8
  • 7
  • 6
  • 6
  • 3
  • 3
  • 2
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 71-170

    Virus Strain

    A/Russia:St.Petersburg/8/2006

    Kreuzreaktivität

    Virus

    Kreuzreaktivität (Details)

    Influenza A virus

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1) Nucleoprotein

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Chen, Angel, Li, Finch, Gonzalez, Sutton, Santos, Perez: "All-in-one bacmids: an efficient reverse genetics strategy for influenza A virus vaccines." in: Journal of virology, Vol. 88, Issue 17, pp. 10013-25, (2014) (PubMed).

  • Target

    Influenza Nucleoprotein (NP)

    Andere Bezeichnung

    Influenza A virus Nucleoprotein

    Substanzklasse

    Influenza Protein

    Hintergrund

    Synonyms: Nucleoprotein, NP, Nucleocapsid protein, Protein N, Influenza A virus H1N1, H3N2 Nucleoprotein, H9N2 Nucleoprotein, H2N2 Nucleoprotein, H3N8 Nucleoprotein, H7N7 Nucleoprotein, H5N1 Nucleoprotein.

    Background: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

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