CTLA4 Antikörper

Produktnummer ABIN135319

Dieses Hamster Monoklonal-Antikörper erkennt spezifisch CTLA4 in ELISA. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CTLA4 Antikörper (ABIN135319)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 9H10

Produktdetails anti-CTLA4 Antikörper

Spezifität: Mouse CD152, Mr 33-37 kDa

Produktmerkmale: Hamster Anti-Mouse CD152-LE/AF

Endotoxin-Niveau: Low endotoxin

Immunogen: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

• Applications: ELISA - Quality tested , FC - Reported in literature , IP - Reported in literature , Costim - Reported in literature , Block - Reported in literature
• Working Dilutions: ELISA Purified (UNLB) antibody 1 g/mL

Kommentare:

In vitro and in vivo blocking of CTLA-4 action by soluble antibody, Promotion of in vitro CTLA-4 signaling by cross-linked antibody

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of PBS

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CD152

Hintergrund: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.

Pathways: Cancer Immune Checkpoints