CD44 Antikörper

Produktnummer ABIN135069

Der Ratte Monoklonal anti-CD44 Antikörper (Klon KM201) (ABIN135069) detektiert spezifisch CD44 in FACS, WB, IHC (p), IP, IHC (fro), ICC, BR und Adh Act. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für CD44 Antikörper (ABIN135069)

Target: CD44

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Blocking Reagent (BR), Adhesion Activation (Adh Act)

Klon: KM201

Produktdetails anti-CD44 Antikörper

Verwendungszweck: Rat Anti-Mouse CD44-LE/AF

Spezifität: Mouse CD44 (all isoforms), Mr 80-95 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD44 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, blocking, and adhesion assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: (C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal clone BMS2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.

Gen-ID: 12505

UniProt: P15379

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling