CD44 Antikörper

Produktnummer ABIN135069

Dieser Anti-CD44 Antikörper ist ein Ratte Monoklonal Antikörper zur Detektion von CD44 in FACS. Geeignet für Maus.

Kurzübersicht für CD44 Antikörper (ABIN135069)

Target: CD44

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: KM201

Produktdetails anti-CD44 Antikörper

Spezifität: Mouse CD44 (all isoforms), Mr 80-95 kDa

Produktmerkmale: Rat Anti-Mouse CD44-LE/AF

Endotoxin-Niveau: Low endotoxin

Immunogen: (C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal clone BMS2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , WB - Reported in literature , Block - Reported in literature , Adhesion - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Kommentare:

cell adhesion and homing

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of PBS

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling