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PDGFRB Antikörper (Platelet Derived Growth Factor Receptor beta) (PE) Primary Antibody

PDGFRB Reaktivität: Human ICC, FACS Wirt: Maus Monoclonal 18A2 PE
Pubmed (1 reference)
Produktnummer ABIN1303108
$484.24
Zzgl. Versandkosten $45.00
100 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle PDGFRB Antikörper anzeigen
    PDGFRB
    Reaktivität
    • 235
    • 103
    • 96
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 210
    • 36
    • 3
    • 2
    Maus
    Klonalität
    • 196
    • 55
    Monoklonal
    Konjugat
    • 134
    • 14
    • 11
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Dieser PDGFRB Antikörper ist konjugiert mit PE
    Applikation
    • 145
    • 104
    • 74
    • 54
    • 53
    • 41
    • 38
    • 30
    • 20
    • 17
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Spezifität
    The monoclonal antibody 18A2 recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
    Kreuzreaktivität (Details)
    Human
    Immunogen
    CD140b-transfected NIH 3T3 cells
    Klon
    18A2
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Fekete, Rojewski, Fürst, Kreja, Ignatius, Dausend, Schrezenmeier: "GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC." in: PLoS ONE, Vol. 7, Issue 8, pp. e43255, (2012) (PubMed).

  • Target
    PDGFRB
    Abstract
    PDGFRB Produkte
    Synonyme
    AI528809, CD140b, PDGFR-1, Pdgfr, CD140B, IBGC4, JTK12, PDGFR, PDGFR1, platelet derived growth factor receptor, beta polypeptide, platelet derived growth factor receptor beta, Pdgfrb, PDGFRB
    Hintergrund
    CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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