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CD40 Ligand Antikörper (FITC)

Dieses Anti-CD40 Ligand-Antikörper ist ein Hamster Monoklonal-Antikörper zur Detektion von CD40 Ligand in FACS. Geeignet für Maus. Dieses Primary Antibody wurde in 8+ Publikationen zitiert.
Produktnummer ABIN1302930

Kurzübersicht für CD40 Ligand Antikörper (FITC) (ABIN1302930)

Target

Alle CD40 Ligand (CD40LG) Antikörper anzeigen
CD40 Ligand (CD40LG)

Reaktivität

  • 197
  • 88
  • 42
  • 12
  • 10
  • 9
  • 6
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Maus

Wirt

  • 122
  • 111
  • 27
  • 11
  • 9
  • 2
  • 1
Hamster

Klonalität

  • 166
  • 112
  • 4
Monoklonal

Konjugat

  • 153
  • 27
  • 25
  • 14
  • 9
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD40 Ligand Antikörper ist konjugiert mit FITC

Applikation

  • 145
  • 142
  • 117
  • 75
  • 67
  • 54
  • 43
  • 22
  • 20
  • 15
  • 13
  • 13
  • 13
  • 7
  • 6
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

MR-1
  • Verwendungszweck

    Anti-Ms CD154 FITC

    Spezifität

    The Armenian hamster monoclonal antibody MR-1 detects an extracellular epitope on murine CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.

    Kreuzreaktivität (Details)

    Mouse

    Aufreinigung

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Activated mouse Th1 clone D1.6

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 2-3 μg/mL, positive control: 6-8 hour activated murine splenocytes.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Shin, Kennedy, Gorski, Tsuchiya, Koseki, Azuma, Yagita, Chen, Powell, Pardoll, Housseau: "Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor." in: The Journal of experimental medicine, Vol. 198, Issue 1, pp. 31-8, (2003) (PubMed).

    Luzina, Atamas, Storrer, daSilva, Kelsoe, Papadimitriou, Handwerger: "Spontaneous formation of germinal centers in autoimmune mice." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 578-84, (2001) (PubMed).

    Hwang, Nahm, Briles, Thomas, Purkerson: "Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L." in: Infection and immunity, Vol. 68, Issue 2, pp. 511-7, (2000) (PubMed).

    Lode, Xiang, Pertl, Förster, Schoenberger, Gillies, Reisfeld: "Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction." in: The Journal of clinical investigation, Vol. 105, Issue 11, pp. 1623-30, (2000) (PubMed).

    Howard, Miga, Vanderlugt, Dal Canto, Laman, Noelle, Miller: "Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis." in: The Journal of clinical investigation, Vol. 103, Issue 2, pp. 281-90, (1999) (PubMed).

    Salgado, Nakamura, Sugaya, Tada, Asahina, Koyama, Irie, Tamaki: "Functional CD40 ligand is expressed on epidermal Langerhans cells." in: Journal of leukocyte biology, Vol. 66, Issue 2, pp. 281-5, (1999) (PubMed).

    Wu, Zhou, Zheng, Liu: "CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen." in: The Journal of experimental medicine, Vol. 187, Issue 7, pp. 1151-6, (1998) (PubMed).

    Noelle, Roy, Shepherd, Stamenkovic, Ledbetter, Aruffo: "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 14, pp. 6550-4, (1992) (PubMed).

  • Target

    CD40 Ligand (CD40LG)

    Andere Bezeichnung

    CD154

    Hintergrund

    CD40 ligand,CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.,CD40L, CD40 ligand, TNFSF5, Ly62, gp39, T-BAM

    Gen-ID

    959

    UniProt

    P29965

    Pathways

    NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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