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CD3 Antikörper (CD3) Primary Antibody

CD3 Reaktivität: Maus FACS, Func, ICC, IHC (fro), IP Wirt: Hamster Monoclonal 145-2C11 unconjugated
Pubmed (9 references)
Produktnummer ABIN1302512
$250.47
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle CD3 Antikörper anzeigen
    CD3
    Reaktivität
    • 235
    • 109
    • 32
    • 25
    • 19
    • 16
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    • 11
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    • 1
    Maus
    Wirt
    • 264
    • 59
    • 20
    • 13
    • 6
    Hamster
    Klonalität
    • 352
    • 6
    Monoklonal
    Konjugat
    • 115
    • 43
    • 33
    • 26
    • 21
    • 11
    • 7
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    • 6
    • 6
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    • 5
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    • 3
    • 3
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    Dieser CD3 Antikörper ist unkonjugiert
    Applikation
    • 321
    • 99
    • 78
    • 66
    • 62
    • 43
    • 40
    • 27
    • 18
    • 17
    • 17
    • 9
    • 7
    • 3
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    • 3
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    • 2
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    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
    Spezifität
    The Armenian hamster monoclonal antibody 145-2C11 reacts with mouse CD3 (epsilon subunit). This antibody is commonly used as a phenotypic marker for mouse T cells.
    Kreuzreaktivität (Details)
    Mouse
    Aufreinigung
    Purified by protein-G affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogen
    Mouse BM10-37 cytotoxic T lymphocytes
    Klon
    145-2C11
    Isotyp
    IgG
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μ,m filter sterilized.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Han, Murray-Segal, Gershenzon, Zhang, Hodder, Pietersz, Mottram: "Idarubicin-145-2C11-F(ab')2 promotes peripheral tolerance and reduces chronic vascular disease in mouse cardiac allografts." in: Transplant immunology, Vol. 7, Issue 4, pp. 207-13, (2000) (PubMed).

    Kearse: "Calnexin associates with monomeric and oligomeric (disulfide-linked) CD3delta proteins in murine T lymphocytes." in: The Journal of biological chemistry, Vol. 273, Issue 23, pp. 14152-7, (1998) (PubMed).

    Henrickson, Reid, Bellet, Sawchuk, Hirsch: "Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11)." in: Transplantation, Vol. 60, Issue 8, pp. 828-35, (1995) (PubMed).

    Vossen, Tibbe, Kroos, van de Winkel, Benner, Savelkoul: "Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects." in: European journal of immunology, Vol. 25, Issue 6, pp. 1492-6, (1995) (PubMed).

    Jacobs, Vandeputte, Tolkamp, de Vries, Borst, Berns: "CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo." in: European journal of immunology, Vol. 24, Issue 4, pp. 934-9, (1994) (PubMed).

    Salvadori, Gansbacher, Pizzimenti, Zier: "Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 11, pp. 5176-82, (1994) (PubMed).

    Payer, Elbe, Stingl: "Circulating CD3+/T cell receptor V gamma 3+ fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 8, pp. 2536-43, (1991) (PubMed).

    Leo, Foo, Sachs, Samelson, Bluestone: "Identification of a monoclonal antibody specific for a murine T3 polypeptide." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 5, pp. 1374-8, (1987) (PubMed).

    Samelson, OShea, Luong, Ross, Urdahl, Klausner, Bluestone: "T cell antigen receptor phosphorylation induced by an anti-receptor antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 8, pp. 2708-14, (1987) (PubMed).

  • Target
    CD3
    Andere Bezeichnung
    CD3 (CD3 Produkte)
    Synonyme
    CD3, AI504783, CD3epsilon, T3e, cd3-gamma, cd3g, cd3g-a, cd3g/d, cd3gd, t3g, CD3e molecule, CD3d molecule, CD3 antigen, epsilon polypeptide, CD3g molecule S homeolog, CD3E, CD3D, Cd3e, cd3g.S
    Hintergrund
    CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
    Pathways
    T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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