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IL3RA Antikörper (Interleukin 3 Receptor, alpha (Low Affinity)) Primary Antibody

IL3RA Reaktivität: Human FACS, IHC (fro), IP, WB Wirt: Maus Monoclonal 6H6 unconjugated
Pubmed (2 references)
Produktnummer ABIN1302506
$333.96
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle IL3RA Antikörper anzeigen
    IL3RA
    Reaktivität
    • 94
    • 31
    • 5
    • 1
    Human
    Wirt
    • 53
    • 44
    • 2
    • 1
    • 1
    Maus
    Klonalität
    • 53
    • 48
    Monoklonal
    Konjugat
    • 56
    • 10
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL3RA Antikörper ist unkonjugiert
    Applikation
    • 54
    • 47
    • 24
    • 19
    • 13
    • 13
    • 11
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    The mouse monoclonal antibody 6H6 recognizes CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
    Klon
    6H6
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Martín-Gayo, Sierra-Filardi, Corbí, Toribio: "Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development." in: Blood, Vol. 115, Issue 26, pp. 5366-75, (2010) (PubMed).

    Herling, Teitell, Shen, Medeiros, Jones: "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin." in: Blood, Vol. 101, Issue 12, pp. 5007-9, (2003) (PubMed).

  • Target
    IL3RA
    Andere Bezeichnung
    CD123 (IL3RA Produkte)
    Synonyme
    CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, CDw123, SUT-1, Cyrl, interleukin 3 receptor subunit alpha, interleukin 3 receptor, alpha chain, IL3RA, Il3ra
    Hintergrund
    CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
    Gen-ID
    3563
    Pathways
    JAK-STAT Signalweg
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